2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

Base Information

Chemical Name:2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide
CAS No.:1428155-44-5
Molecular Formula:C₂₄H₂₃N₅O₃
Molecular Weight:429.478
Hs Code.:

Synonyms:2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

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Chemical Property of 2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

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Technology Process of 2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

There total 4 articles about 2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1428155-06-9
3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)aniline

: 579-75-9
2-Methoxybenzoic acid

: 1428155-44-5
2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-44-5
2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 15 h / 100 °C / Inert atmosphere; Sealed tube

2: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; ethanol; dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 1428155-05-8
6-(3-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-44-5
2-methoxy-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2012.06.005