N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

Base Information

Chemical Name:N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine
CAS No.:1453835-16-9
Molecular Formula:C₂₄H₃₀N₈
Molecular Weight:430.556
Hs Code.:

Synonyms:N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

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Chemical Property of N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

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Technology Process of N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

There total 11 articles about N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₈N₈O₂

: 1453835-16-9
N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;

Reference yield:

: 1453837-36-9
N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(methylthio)-pyrazolo[1,5-a][1,3,5]triazin-4-amine

: 1453835-16-9
N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 30 °C

2.1: water; lithium hydroxide / 1,4-dioxane / 60 °C

3.1: N,N-diethylaniline; phosphorus(V) oxybromide / toluene / 100 °C

4.1: dmap / tetrahydrofuran / 20 °C

5.1: 9-borabicyclo[3.3.1]nonane / 7 h / Reflux

5.2: 2.5 h / 60 °C

6.1: trifluoroacetic acid / dichloromethane / 0 °C

With dmap; 9-borabicyclo[3.3.1]nonane; water; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; N,N-diethylaniline; lithium hydroxide; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 151521-49-2
4-isopropyl-1 H-pyrazol-5-amine

: 1453835-16-9
N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: dichloromethane / 2 h

2.1: acetonitrile / 2 h / Reflux

3.1: sodium hydroxide / water; ethanol / Cooling with ice

4.1: N,N-diethylaniline; trichlorophosphate / 3 h / 90 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 30 °C

7.1: water; lithium hydroxide / 1,4-dioxane / 60 °C

8.1: N,N-diethylaniline; phosphorus(V) oxybromide / toluene / 100 °C

9.1: dmap / tetrahydrofuran / 20 °C

10.1: 9-borabicyclo[3.3.1]nonane / 7 h / Reflux

10.2: 2.5 h / 60 °C

11.1: trifluoroacetic acid / dichloromethane / 0 °C

With dmap; 9-borabicyclo[3.3.1]nonane; water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; N,N-diethylaniline; sodium hydroxide; lithium hydroxide; trichlorophosphate; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;