1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidine Mono(trifluoroacetate)

Base Information

• Chemical Name: 1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidine Mono(trifluoroacetate)
• CAS No.: 144646-34-4
• Molecular Formula: C15H19F3N2O3
• Molecular Weight: 0
• Mol file: 144646-34-4.mol

Synonyms:(S)-1-(2-Amino-1-oxo-3-phenylpropyl)pyrrolidine Mono(trifluoroacetate);1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidine Mono(trifluoroacetate)

Chemical Property of 1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidine Mono(trifluoroacetate)

Chemical Property:

• PSA: 83.63000
• LogP: 2.97040
• Solubility.: Methanol

Purity/Quality:

99% ^*data from raw suppliers

1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidineMono(TrifluoroaceticAcidSalt) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidine Mono(trifluoroacetate)

There total 3 articles about 1-[(2S)-Amino-1-oxo-3-phenylpropyl]pyrrolidine Mono(trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoroacetic acid (76-05-1) + Nα-(tert-butoxycarbonyl)-L-phenylalanine-N-pyrrolidinamide (125139-05-1) → 1-(L-phenylalanyl)pyrrolidine trifluoroacetate (144646-34-4)

Guidance literature:

In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jm030811o

Reference yield:

Boc-Phe-ONSu (3674-06-4) → 1-(L-phenylalanyl)pyrrolidine trifluoroacetate (144646-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: CH₂Cl₂ / 2 h / 0 °C

In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm030811o

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → 1-(L-phenylalanyl)pyrrolidine trifluoroacetate (144646-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBt; PS-carbodiimide / CH₂Cl₂ / 0.17 h

1.2: CH₂Cl₂ / 20 °C

2.1: CH₂Cl₂ / 3 h

With PS-carbodiimide; benzotriazol-1-ol; In dichloromethane;

DOI:10.1021/jm0308803

upstream raw materials:

trifluoroacetic acid

N^α-(tert-butoxycarbonyl)-L-phenylalanine-N-pyrrolidinamide

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Phe-ONSu

Refernces

• 1、 Senten, Kristel,Van der Veken, Pieter,De Meester, Ingrid,Lambeir, Anne-Marie,Scharpé, Simon,Haemers, Achiel,Augustyns, Koen. "Design, Synthesis, and SAR of Potent and Selective Dipeptide-Derived Inhibitors for Dipeptidyl Peptidases". . p. 5005 - 5014. Retrieved 2007/10/03.