(S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

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Chemical Name:(S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate
CAS No.:950751-56-1
Molecular Formula:C₃₀H₂₆N₄O₄
Molecular Weight:506.561
Hs Code.:

Synonyms:(S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

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Chemical Property of (S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

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Technology Process of (S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

There total 7 articles about (S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950751-41-4
(3aR,10aS)-3a-ethyl 4-methyl 3-oxo-3a,10a-dihydro-1H,10H-furo[3,4-c]pyrrolo[1,2-a]indole-3a,4-dicarboxylate

: 950751-56-1
(S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: aq. NaOH / ethanol / Heating

1.2: aq. HCl / ethanol / Heating

2.1: N-methylmorpholine / N,N-dimethyl-acetamide / cooling

3.1: toluene; N,N-dimethyl-acetamide / 6.5 h / 100 °C

4.1: hydrazine hydrate / toluene / 6 h / 80 °C

5.1: aq. K₂CO₃ / toluene / 1.5 h / cooling

6.1: NaH₂PO₄ / ethane-1,2-diol; various solvent(s) / 2 h / 110 °C

7.1: ethane-1,2-diol; various solvent(s) / 43 h / 110 °C

With 4-methyl-morpholine; sodium hydroxide; sodium dihydrogenphosphate; potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl acetamide; ethylene glycol; toluene; 3.1: Gabriel synthesis;
DOI:10.1021/ol071336h

Reference yield:

: 257876-34-9
C₁₃H₁₅NO₃S

: 950751-56-1
(S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene; N,N-dimethyl-acetamide / 6.5 h / 100 °C

2: hydrazine hydrate / toluene / 6 h / 80 °C

3: aq. K₂CO₃ / toluene / 1.5 h / cooling

4: NaH₂PO₄ / ethane-1,2-diol; various solvent(s) / 2 h / 110 °C

5: ethane-1,2-diol; various solvent(s) / 43 h / 110 °C

With sodium dihydrogenphosphate; potassium carbonate; hydrazine hydrate; In N,N-dimethyl acetamide; ethylene glycol; toluene; 1: Gabriel synthesis;
DOI:10.1021/ol071336h

Reference yield:

: 950751-53-8
(S)-2-(2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-ylmethyl)isoindole-1,3-dione

: 950751-56-1
(S)-benzyl ({9-[4-(phenylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl}methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / toluene / 6 h / 80 °C

2: aq. K₂CO₃ / toluene / 1.5 h / cooling

3: NaH₂PO₄ / ethane-1,2-diol; various solvent(s) / 2 h / 110 °C

4: ethane-1,2-diol; various solvent(s) / 43 h / 110 °C

With sodium dihydrogenphosphate; potassium carbonate; hydrazine hydrate; In ethylene glycol; toluene;
DOI:10.1021/ol071336h