cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene

Base Information

• Chemical Name: cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene
• CAS No.: 100899-25-0
• Molecular Formula: C₁₉H₂₃NO₄S
• Molecular Weight: 361.462

Synonyms:cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene

Chemical Property of cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene

There total 2 articles about cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

cis-N-tosyl-4-iodo-3-methyl-2-azabicyclo<3.3.0>oct-3-ene (100899-20-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene (100899-25-0)

Guidance literature:

With palladium diacetate; tributyl-amine; tris-(o-tolyl)phosphine; at 100 ℃; for 24h;

DOI:10.1021/jo00358a003

Reference yield:

cis-1,3a,4,5,6,6a-hexahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-cyclopenta[b]pyrrole (81097-07-6) → cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene (100899-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodosuccinimide / CCl₄ / 1 h

2: 48 percent / Pd(OAc)2, P(o-tol)3, n-Bu₃N / 24 h / 100 °C

With palladium diacetate; N-iodo-succinimide; tributyl-amine; tris-(o-tolyl)phosphine; In tetrachloromethane;

DOI:10.1021/jo00358a003

Reference yield: 39.0%

maleic anhydride (108-31-6) + cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene (100899-25-0) → (5bR,8aR)-9a-Methyl-1,3-dioxo-9-(toluene-4-sulfonyl)-1,3,4,5,5a,5b,6,7,8,8a,9,9a-dodecahydro-2-oxa-9-aza-cyclopenta[b]-as-indacene-4-carboxylic acid methyl ester (100899-31-8)

Guidance literature:

In benzene; for 44h; Heating;

DOI:10.1021/jo00358a003

upstream raw materials:

cis-N-tosyl-4-iodo-3-methyl-2-azabicyclo<3.3.0>oct-3-ene

acrylic acid methyl ester

cis-1,3a,4,5,6,6a-hexahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-cyclopenta[b]pyrrole

Downstream raw materials:

(5bR,8aR)-9a-Methyl-1,3-dioxo-9-(toluene-4-sulfonyl)-1,3,4,5,5a,5b,6,7,8,8a,9,9a-dodecahydro-2-oxa-9-aza-cyclopenta[b]-as-indacene-4-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 100899-25-0 cis-N-tosyl-4-(2-carbomethoxyethen-1-yl)-3-methyl-2-azabicyclo<3.3.0>oct-3-ene

Send

Send

Metric Ton KG G Pound L ML

Send

Send