Fmoc-D-DMPT-Pro-OPfp

Base Information

Chemical Name:Fmoc-D-DMPT-Pro-OPfp
CAS No.:141636-69-3
Molecular Formula:C₃₂H₂₇F₅N₂O₅S
Molecular Weight:646.635
Hs Code.:

Synonyms:Fmoc-D-DMPT-Pro-OPfp

Suppliers and Price of Fmoc-D-DMPT-Pro-OPfp

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Fmoc-D-DMPT-Pro-OPfp

Chemical Property:

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Technology Process of Fmoc-D-DMPT-Pro-OPfp

There total 5 articles about Fmoc-D-DMPT-Pro-OPfp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 141636-68-2
Fmoc-D-DMTP-Pro-OH

: 141636-69-3
Fmoc-D-DMPT-Pro-OPfp

Guidance literature:: With dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide; at 5 - 20 ℃; for 3h;
DOI:10.1021/jm00092a008

Reference yield:

: 52-67-5
3,3-dimethyl-D-cysteine

: 141636-69-3
Fmoc-D-DMPT-Pro-OPfp

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / H₂O / 23 h / 0 - 20 °C

2: 83 percent / aq. NaOH / 22 h / 0 - 20 °C

3: 1.) Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl), 2.) Et₃N / 1.) CH₂Cl₂, -15 deg C, 20 min, 2.) CH₂Cl₂, 0 deg C, 4 h

4: 94 percent / TFA, H₂O / 1 h / 20 °C

5: 100 percent / dicyclohexylcarbodiimide / ethyl acetate; dimethylformamide / 3 h / 5 - 20 °C

With water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In sodium hydroxide; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a008

Reference yield:

: 141636-66-0,753030-79-4
Fmoc-D-5,5-dimethylthiaproline

: 141636-69-3
Fmoc-D-DMPT-Pro-OPfp

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl), 2.) Et₃N / 1.) CH₂Cl₂, -15 deg C, 20 min, 2.) CH₂Cl₂, 0 deg C, 4 h

2: 94 percent / TFA, H₂O / 1 h / 20 °C

3: 100 percent / dicyclohexylcarbodiimide / ethyl acetate; dimethylformamide / 3 h / 5 - 20 °C

With water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a008