2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

Base Information

Chemical Name:2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole
CAS No.:1416046-10-0
Molecular Formula:C₂₆H₂₇N₂OP
Molecular Weight:414.487
Hs Code.:

Synonyms:2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

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Chemical Property of 2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

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Technology Process of 2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

There total 5 articles about 2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1416046-08-6
2-[(2S)-2-(bromomethyl)pyrrolidin-1-yl]-1,3-benzoxazole

: 29949-64-2
di(o-tolyl)phosphine

: 1416046-10-0
2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

Guidance literature:: di(o-tolyl)phosphine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.33h;

2-[(2S)-2-(bromomethyl)pyrrolidin-1-yl]-1,3-benzoxazole; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 19h;
DOI:10.1002/hlca.201200437

Reference yield:

: 615-18-9
2-chloro-1,3-benzoxazole

: 1416046-10-0
2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 20 °C

1.2: 14 h / -78 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 17 h / 0 - 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.33 h / -78 - 20 °C

4.2: 19 h / -78 - 20 °C

With n-butyllithium; carbon tetrabromide; tetra-n-butylammoniumfluoride trihydrate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 3.1: |Appel Halogenation;
DOI:10.1002/hlca.201200437

Reference yield:

: 134756-75-5
(2S)-2-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)pyrrolidine

: 1416046-10-0
2-[ (2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 20 °C

1.2: 14 h / -78 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 17 h / 0 - 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.33 h / -78 - 20 °C

4.2: 19 h / -78 - 20 °C

With n-butyllithium; carbon tetrabromide; tetra-n-butylammoniumfluoride trihydrate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 3.1: |Appel Halogenation;
DOI:10.1002/hlca.201200437