(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

Base Information

Chemical Name:(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine
CAS No.:864515-64-0
Molecular Formula:C₁₆H₂₉NO₂Si
Molecular Weight:295.497
Hs Code.:

Synonyms:(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

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Chemical Property of (1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

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Technology Process of (1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

There total 1 articles about (1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 51594-34-4
(1S,2S)-2-amino-3-methoxy-1-phenyl-1-propanol

: 69739-34-0
t-butyldimethylsiyl triflate

: 864515-64-0
(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; cooling;
DOI:10.1021/ja043999p

Reference yield: 75.0%

: 864515-64-0
(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

: 360789-47-5
N,N-bis(1-methylethyl)-α-oxobenzeneacetamide-4-carboxylic acid

: 864515-54-8
N-[2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-4-diisopropylaminooxalyl-benzamide

Guidance literature:: N,N-bis(1-methylethyl)-α-oxobenzeneacetamide-4-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;

(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja043999p

Reference yield:

: 864515-64-0
(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethylamine

: 4-(3-Hydroxy-1-isopropyl-2,2-dimethyl-4-oxo-azetidin-3-yl)-N-((1S,2S)-2-hydroxy-1-methoxymethyl-2-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 75 percent / CH₂Cl₂ / 2 h / 20 °C

2.1: 82 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

3.1: acetonitrile / UV-irradiation; cooling

With tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; acetonitrile; 3.1: Yang cyclization;
DOI:10.1021/ja043999p