(7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1363479-21-3
Molecular Formula:C₃₂H₂₉N₄O₁₂PS
Molecular Weight:724.642
Hs Code.:

Synonyms:(7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Chemical Property of (7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Technology Process of (7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 18 articles about (7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1363480-92-5
(7-carbamoyl-3-(5-(2-((di-tert-butoxyphosphoryl)oxy)ethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)-methyl phenylmethanesulfonate

: 1363479-21-3
(7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm201717y

Reference yield:

: 885227-29-2
tert-butyl 1-(chloromethyl)-7-cyano-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

: 1363479-21-3
(7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: pyridine / 2 h / 0 °C

3: sodium iodide / butanone / Reflux

4: acetic acid / 48 h / Reflux

5: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

6: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

7: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 4 h / 20 °C

8: pyridine / 1 h / 0 °C

9: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With pyridine; sulfuric acid; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; trifluoroacetic acid; sodium iodide; In dichloromethane; N,N-dimethyl acetamide; water; acetic acid; dimethyl sulfoxide; butanone;
DOI:10.1021/jm201717y

Reference yield:

: 885228-22-8
5-(2-((di-tert-butoxyphosphoryl)oxy)ethoxy)-1H-indole-2-carboxylic acid

: 1363479-21-3
(7-carbamoyl-5-nitro-3-(5-(2-(phosphonooxy)ethoxy)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 4 h / 20 °C

2: pyridine / 1 h / 0 °C

3: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With pyridine; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm201717y