(-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

Base Information

Chemical Name:(-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine
CAS No.:697755-19-4
Molecular Formula:C₁₇H₁₇Cl₂NO
Molecular Weight:322.234
Hs Code.:

Synonyms:(-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

Chemical Property:

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Technology Process of (-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

There total 9 articles about (-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: (+)-trans-1-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-1-methyl-3-(1-naphthalen-2-ylethyl)urea

: 697755-19-4
(-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

Guidance literature:: With aniline; lithium chloride; at 150 ℃; for 6h;
DOI:10.1021/jm0305873

Reference yield:

: 86939-52-8
3-(3,4-dichlorophenyl)-6-methoxyindan-1-ol

: 697755-19-4
(-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / dioxane / 3 h / 20 °C

2: toluene / 60 h / 40 °C

3: benzene / 1 h / 20 °C

4: 69 percent / LiCl; aniline / 6 h / 150 °C

With thionyl chloride; aniline; lithium chloride; In 1,4-dioxane; toluene; benzene;
DOI:10.1021/jm0305873

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 697755-19-4
(-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-methoxy-N-methyl-1-indanamine

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / KOH / ethanol; H₂O

2: 76.8 percent / trifluoroacetic acid / 4 h / 120 °C

3: 76 percent / NaBH₄ / methanol / 2 h / 20 °C

4: SOCl₂ / dioxane / 3 h / 20 °C

5: toluene / 60 h / 40 °C

6: benzene / 1 h / 20 °C

7: 69 percent / LiCl; aniline / 6 h / 150 °C

With potassium hydroxide; sodium tetrahydroborate; thionyl chloride; aniline; trifluoroacetic acid; lithium chloride; In 1,4-dioxane; methanol; ethanol; water; toluene; benzene;
DOI:10.1021/jm0305873