9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

Base Information

Chemical Name:9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
CAS No.:1350816-51-1
Molecular Formula:C₂₃H₂₃Cl₂N₅O
Molecular Weight:456.375
Hs Code.:

Synonyms:9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

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Chemical Property of 9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

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Technology Process of 9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

There total 9 articles about 9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: C₁₂H₁₉ClN₄*ClH

: 87379-40-6
8-chloro-4<(dimethylamino)methylidene>-3,4-dihydro-1H-1-benzazepine-2,5-dione

: 1350816-51-1
9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

Guidance literature:: With potassium carbonate; In ethanol; at 125 ℃; Inert atmosphere;
DOI:10.1021/jm2011172

Reference yield:

: 7223-38-3
N,N-Dimethylpropargylamin

: 1350816-51-1
9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro bis(acetonitrile) palladium(II); caesium carbonate; XPhos / N,N-dimethyl-formamide / 16 h / 50 °C / Inert atmosphere

2: hydrogen; pyrographite; sulfur; platinum / methanol / 2.83 h / 20 °C

3: mercury (II) chloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: potassium carbonate / ethanol / 125 °C / Inert atmosphere

With hydrogenchloride; dichloro bis(acetonitrile) palladium(II); hydrogen; potassium carbonate; pyrographite; caesium carbonate; sulfur; mercury (II) chloride; triethylamine; platinum; XPhos; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2011172

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 1350816-51-1
9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 10 °C

2.2: 20 °C / pH 4

3.1: water / dimethyl sulfoxide / 150 °C / Cooling

3.2: 0 °C

4.1: tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

5.1: potassium carbonate / ethanol / 125 °C / Inert atmosphere

With dmap; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2.1: Dieckmann reaction;
DOI:10.1021/jm2011172