N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

Base Information

Chemical Name:N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide
CAS No.:1395414-23-9
Molecular Formula:C₂₂H₁₆F₆N₂O₃S
Molecular Weight:502.437
Hs Code.:

Synonyms:N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

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Chemical Property of N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

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Technology Process of N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

There total 3 articles about N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 53985-43-6
3-methanesulfonyl-5-trifluoromethylbenzoic acid

: 1395416-12-2
(2,2-difluoro-ethyl)-[4-(2-fluoro-phenyl)-pyridin-3-yl]-amine

: 1395414-23-9
N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1215205-96-1
1-bromo-3-(methylsulfonyl)-5-(trifluoromethyl)benzene

: 1395414-23-9
N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 20 h / 110 °C / 52505.3 Torr

2: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate / dichloromethane / 24 h / 20 °C

With lithium hydroxide monohydrate; water; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: 1395415-86-7
3-methanesulfonyl-5-trifluoromethylbenzoic acid methyl ester

: 1395414-23-9
N-(2,2-difluoro-ethyl)-N-[4-(2-fluoro-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate / dichloromethane / 24 h / 20 °C

With lithium hydroxide monohydrate; water; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;