7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

Base Information

Chemical Name:7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester
CAS No.:813433-40-8
Molecular Formula:C₂₅H₃₆O₃SSi
Molecular Weight:444.711
Hs Code.:

Synonyms:7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

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Chemical Property of 7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

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Technology Process of 7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

There total 5 articles about 7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-(tert-butyl-diphenyl-silanyloxy)-1-ethylsulfanyl-1-trimethylsilanyloxy-hept-1-en-3-ol

: 813433-40-8
7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/ol047998d

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 813433-40-8
7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / imidazole / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 98 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3: Yb(OTf)3 / CH₂Cl₂ / 1 h / 0 °C

4: 14.50 g / aq. HCl / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; hydrogenchloride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; ytterbium(III) triflate; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1021/ol047998d

Reference yield:

: 131216-47-2
5-(tert-butyldiphenylsilyloxy)pentanal

: 813433-40-8
7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyheptanethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Yb(OTf)3 / CH₂Cl₂ / 1 h / 0 °C

2: 14.50 g / aq. HCl / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; ytterbium(III) triflate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol047998d