(S)-2-(2-NAPHTHYL)GLYCOLIC ACID

Base Information

• Chemical Name: (S)-2-(2-NAPHTHYL)GLYCOLIC ACID
• CAS No.: 144371-23-3
• Molecular Formula: C12H10 O3
• Molecular Weight: 202.21
• Mol file: 144371-23-3.mol

Synonyms:2-Naphthaleneaceticacid, a-hydroxy-, (S)-

Chemical Property of (S)-2-(2-NAPHTHYL)GLYCOLIC ACID

Chemical Property:

• Boiling Point: 428.9±25.0 °C(Predicted)
• PKA: 3.42±0.30(Predicted)
• PSA: 57.53000
• Density: 1.354±0.06 g/cm3(Predicted)
• LogP: 1.95780

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-(2-NAPHTHYL)GLYCOLIC ACID 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-(2-NAPHTHYL)GLYCOLIC ACID

There total 11 articles about (S)-2-(2-NAPHTHYL)GLYCOLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(naphthalen-2-yl)-2-oxoacetic acid (14289-45-3) → (S)-2-hydroxy-2-(naphthalen-2-yl)acetic acid (144371-23-3)

Guidance literature:

With [iridium(dihydride)(chloride)((3,5-(tBu)2-C₆H₃)2P)(C₁₇H₁₀)NHCHC₅H₃N(CH₃)]; potassium tert-butylate; hydrogen; In butan-1-ol; at 25 - 30 ℃; for 12h; under 11400.8 Torr; Reagent/catalyst; enantioselective reaction; Autoclave;

DOI:10.1039/c4cc07643e

Reference yield: 98.0%

→ (S)-2-hydroxy-2-(naphthalen-2-yl)acetic acid (144371-23-3)

Guidance literature:

With potassium tert-butylate; hydrogen; In ethanol; at 20 ℃; for 24h; under 11400.8 Torr; Inert atmosphere; Autoclave;

Reference yield: 24.0%

C8H11N*C12H10O3 → (S)-2-hydroxy-2-(naphthalen-2-yl)acetic acid (144371-23-3)

Guidance literature:

With hydrogenchloride; In water;

upstream raw materials:

(RS)-2-naphthylglycolic acid

2,2-dichloro-1-(naphthalen-2-yl)ethan-1-one

methyl 2-naphthyl ketone

2-(naphthalen-2-yl)-2-oxoacetic acid

Refernces

• 1、 Guo, Huan,Li, Jing,Liu, Delong,Zhang, Wanbin. "The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation". . p. 3665 - 3673. Retrieved 2017/09/11.
• 2、 -. "Nitrilases". Paragraph 0495. . Retrieved 2015/09/22.