(5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:(5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1292904-33-6
Molecular Formula:C₃₀H₄₀N₄O
Molecular Weight:472.674
Hs Code.:

Synonyms:(5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of (5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of (5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 7 articles about (5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1183819-04-6
C₁₄H₂₃N

: C₁₆H₁₈ClN₃O

: 1292904-33-6
(5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With triethylamine; In toluene; at 70 ℃; for 3h;
DOI:10.1016/j.bmc.2011.02.001

Reference yield:

: 667920-89-0,667930-75-8,667930-76-9
ethyl 2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate

: 1292904-33-6
(5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: CHIRALCEL OD / ethanol; hexane / 30 °C / Resolution of racemate

2.1: potassium hydroxide / ethanol; water / 16 h / 90 °C

2.2: pH 4

3.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

4.1: triethylamine / toluene / 3 h / 70 °C

With thionyl chloride; triethylamine; potassium hydroxide; In ethanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.02.001

Reference yield:

: 667930-86-1
(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1292904-33-6
(5R)-N-[1-ethyl-1-(4-isopropylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

2: triethylamine / toluene / 3 h / 70 °C

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.02.001