1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil

Base Information

• Chemical Name: 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil
• CAS No.: 129678-82-6
• Molecular Formula: C₄₂H₅₀N₂O₆Si₂
• Molecular Weight: 735.04

Synonyms:1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil

Chemical Property of 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil

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Technology Process of 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil

There total 1 articles about 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-[(2R,3S,4S,5S)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-hydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione (129678-54-2) + tert-butylchlorodiphenylsilane (58479-61-1) → 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil (129678-82-6)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00171a024

Reference yield: 64.0%

1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-3-deoxy-β-D-arabino-pentofuranosyl>uracil (129678-82-6) → 1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil (129678-83-7)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00171a024

upstream raw materials:

1-[(2R,3S,4S,5S)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-hydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

tert-butylchlorodiphenylsilane

Downstream raw materials:

1-<5-O-(tert-butyldiphenylsilyl)-3-C-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dideoxy-2-fluoro-β-D-ribo-pentofuranosyl>uracil

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