tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Base Information

Chemical Name:tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide
CAS No.:77511-58-1
Molecular Formula:C₅₄H₈₈N₁₀O₁₄S
Molecular Weight:1133.42
Hs Code.:

tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Synonyms:tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

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Technology Process of tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

There total 5 articles about tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 30845-24-0
N-tert-butyloxycarbonyl-O-tert-butyltyrosine N-hydroxysuccinimide ester

: 77511-55-8
isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

: 77511-58-1
tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Guidance literature:: With 1-ethyl-piperidine; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1135/cccc19802714

Reference yield:

: 30845-18-2
4-{(R)-3-{(S)-2-[(S)-1-(Carbamoylmethyl-carbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-2-[(S)-3-carbamoyl-2-(2-nitro-phenylsulfanylamino)-propionylamino]-3-oxo-propylsulfanyl}-butyric acid methyl ester

: 77511-58-1
tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. HCl; 2.) N-ethylpiperidine / 1.) CH₃OH, ether; 2.) DMF, room temperature.

2: 1.) HCl; 2.) N-ethylpiperidine / 1.) DMF, ether, room temp.; 2.) DMF_.

3: 47 percent / HCl, NaOH / dimethylformamide; diethyl ether; methanol / 1 h / Ambient temperature

4: 98 percent / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1135/cccc19802714

Reference yield:

: 77511-46-7
o-nitrobenzenesulphenylisoleucyl-asparaginyl-S-(γ-methoxycarbonylpropyl)cysteinyl-prolyl-leucyl-glycinamide

: 77511-58-1
tert-butyloxycarbonyl-O-tert-butyltyrosyl-isoleucyl-isoleucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HCl; 2.) N-ethylpiperidine / 1.) DMF, ether, room temp.; 2.) DMF_.

2: 47 percent / HCl, NaOH / dimethylformamide; diethyl ether; methanol / 1 h / Ambient temperature

3: 98 percent / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1135/cccc19802714