C₁₅H₂₁NO₃*C₂HF₃O₂

Base Information

Chemical Name:C₁₅H₂₁NO₃*C₂HF₃O₂
CAS No.:1586801-09-3
Molecular Formula:C₂HF₃O₂*C₁₅H₂₁NO₃
Molecular Weight:377.361
Hs Code.:

C<sub>15</sub>H<sub>21</sub>NO<sub>3</sub>*C<sub>2</sub>HF<sub>3</sub>O<sub>2</sub>

Synonyms:C₁₅H₂₁NO₃*C₂HF₃O₂

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Chemical Property of C₁₅H₂₁NO₃*C₂HF₃O₂

Chemical Property:

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Technology Process of C₁₅H₂₁NO₃*C₂HF₃O₂

There total 19 articles about C₁₅H₂₁NO₃*C₂HF₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1543006-56-9
C₂₀H₂₉NO₅

: 76-05-1
trifluoroacetic acid

: 1586801-09-3
C₁₅H₂₁NO₃*C₂HF₃O₂

Guidance literature:: In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2013.12.078

Reference yield:

: 1543006-73-0
(2R,3S)-2-allyl-5-(benzyloxy)pentane-1,3-diol

: 1586801-09-3
C₁₅H₂₁NO₃*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 18 steps

1.1: camphor-10-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; toluene / 4 h / 20 °C / Inert atmosphere

3.1: sodium periodate / tetrahydrofuran; aq. phosphate buffer / 0.75 h / 0 °C / pH Ca_. 7 / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

5.1: triethylamine; dmap / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

6.1: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

7.1: acetic acid; water / 3 h / 100 °C / Inert atmosphere

8.1: triethylamine; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

9.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

10.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

10.2: 36 h / Inert atmosphere; Reflux

11.1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

12.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h

13.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

13.2: 1 h / -78 - 0 °C / Inert atmosphere

14.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

15.1: diethyl ether / 0 °C / Inert atmosphere

16.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

17.1: silver(l) oxide / diethyl ether / 36 h / 20 °C / Inert atmosphere

18.1: dichloromethane / 1 h / 0 °C / Inert atmosphere

With dmap; sodium chlorite; sodium tetrahydroborate; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sodium azide; 2-methyl-but-2-ene; oxalyl dichloride; palladium 10% on activated carbon; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; water; hydrogen; acetic acid; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; methanol; aq. phosphate buffer; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1016/j.tet.2013.12.078

Reference yield:

: 1543006-77-4
(4S,5R)-5-allyl-4-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxane

: 1586801-09-3
C₁₅H₂₁NO₃*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 17 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; toluene / 4 h / 20 °C / Inert atmosphere

2.1: sodium periodate / tetrahydrofuran; aq. phosphate buffer / 0.75 h / 0 °C / pH Ca_. 7 / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

4.1: triethylamine; dmap / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

5.1: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

6.1: acetic acid; water / 3 h / 100 °C / Inert atmosphere

7.1: triethylamine; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

9.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

9.2: 36 h / Inert atmosphere; Reflux

10.1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

11.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h

12.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

12.2: 1 h / -78 - 0 °C / Inert atmosphere

13.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

14.1: diethyl ether / 0 °C / Inert atmosphere

15.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

16.1: silver(l) oxide / diethyl ether / 36 h / 20 °C / Inert atmosphere

17.1: dichloromethane / 1 h / 0 °C / Inert atmosphere

With dmap; sodium chlorite; sodium tetrahydroborate; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sodium azide; 2-methyl-but-2-ene; oxalyl dichloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; acetic acid; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; methanol; aq. phosphate buffer; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1016/j.tet.2013.12.078