(2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

Base Information

Chemical Name:(2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one
CAS No.:439264-88-7
Molecular Formula:C₁₈H₂₂O₅
Molecular Weight:318.37
Hs Code.:

Synonyms:(2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

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Chemical Property of (2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

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Technology Process of (2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

There total 13 articles about (2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4-(7-hydroxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-butyric acid

: 439264-88-7
(2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

Guidance literature:: 4-(7-hydroxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-butyric acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃;

With dmap; In toluene; at 100 ℃;
DOI:10.1016/j.tetlet.2007.03.041

Reference yield:

: 4-((2R,4aR,9aS)-7-Hydroxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-butyric acid

: 439264-88-7
(2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

Guidance literature:: 4-((2R,4aR,9aS)-7-Hydroxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-butyric acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With dmap; In tetrahydrofuran; benzene; at 20 ℃; for 11h; Further stages.;
DOI:10.1021/jo025566f

Reference yield:

: 4-(7-hydroxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-but-2-enoic acid ethyl ester

: 439264-88-7
(2R,4aR,5aS,10aR,12aS)-2-Phenyl-decahydro-1,3,5,10-tetraoxa-benzo[b]heptalen-9-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethyl acetate / 20 °C

2.1: LiOH*H₂O / tetrahydrofuran; H₂O / 45 °C

3.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran / 20 °C

3.2: 88 percent / DMAP / toluene / 100 °C

With lithium hydroxide; 2,4,6-trichlorobenzoyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1016/j.tetlet.2007.03.041