12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

Base Information

Chemical Name:12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one
CAS No.:847573-86-8
Molecular Formula:C₂₉H₂₇N₃O₅
Molecular Weight:497.55
Hs Code.:

12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12<i>H</i>-8,10-dioxa-6,12-diaza-cyclopenta[<i>b</i>]chrysen-13-one

Synonyms:12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

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Chemical Property of 12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

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Technology Process of 12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

There total 10 articles about 12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 847573-78-8
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-methylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

: 847573-86-8
12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

Guidance literature:: With palladium diacetate; tris-(o-tolyl)phosphine; silver carbonate; In N,N-dimethyl-formamide; for 0.5h; Heating;
DOI:10.1021/jm049447z

Reference yield:

: 14165-18-5
N-benzyl-N-methylethylenediamine

: 847573-86-8
12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenol / 2.5 h / Heating

1.2: 65 percent / phenol / 20 h / Heating

2.1: 1.44 g / Et₃N / CH₂Cl₂ / 16 h / Heating

3.1: 35 percent / Pd(OAc)2; P(o-tolyl)3; Ag₂CO₃ / dimethylformamide / 0.5 h / Heating

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; silver carbonate; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049447z

Reference yield:

: 14321-25-6
(N-benzyl-N-methylamino)acetonitrile

: 847573-86-8
12-[2-(benzyl-methyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiAlH₄ / tetrahydrofuran

2.1: phenol / 2.5 h / Heating

2.2: 65 percent / phenol / 20 h / Heating

3.1: 1.44 g / Et₃N / CH₂Cl₂ / 16 h / Heating

4.1: 35 percent / Pd(OAc)2; P(o-tolyl)3; Ag₂CO₃ / dimethylformamide / 0.5 h / Heating

With palladium diacetate; lithium aluminium tetrahydride; triethylamine; tris-(o-tolyl)phosphine; silver carbonate; phenol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049447z