Carbamic acid, (2-fluoro-1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, (2-fluoro-1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester
• CAS No.: 144168-04-7
• Molecular Formula: C₉H₁₆FNO₃
• Molecular Weight: 205.229
• Mol file: 144168-04-7.mol

Synonyms:Carbamic acid, (2-fluoro-1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester

Chemical Property of Carbamic acid, (2-fluoro-1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of Carbamic acid, (2-fluoro-1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, (2-fluoro-1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Boc-Aib-OH (30992-29-1) → tert-butyl (1-fluoro-2-methyl-1-oxopropan-2-yl)carbamate (144168-04-7)

Guidance literature:

With trifluoro-[1,3,5]triazine; triethylamine; In dichloromethane; at -40 - -10 ℃; for 1h;

Reference yield:

tert-butyl (1-fluoro-2-methyl-1-oxopropan-2-yl)carbamate (144168-04-7) → 5-(2-((tert-butoxycarbonyl)amino)propan-2-yl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 40 °C

With lithium hydroxide monohydrate; water; potassium hexamethylsilazane; In tetrahydrofuran;

Reference yield:

tert-butyl (1-fluoro-2-methyl-1-oxopropan-2-yl)carbamate (144168-04-7) → tert-butyl (2-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)propan-2-yl)carbamate

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 40 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 0.5 h / 20 °C

3.2: 12 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; water; potassium hexamethylsilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

Boc-Aib-OH

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