6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Base Information

Chemical Name:6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid
CAS No.:1557247-72-9
Molecular Formula:C₁₆H₂₈N₂O₃Si
Molecular Weight:324.495
Hs Code.:

Synonyms:6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Suppliers and Price of 6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6,6-Dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylicacid 97%
1g
$ 1191.00

Chemenu
6,6-Dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylicacid 97%
1g
$ 1122.00

Total 1 raw suppliers

Chemical Property of 6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Chemical Property:

Boiling Point:434.8±45.0 °C(Predicted)
Density:1.11±0.1 g/cm3(Predicted)

Purity/Quality:: 6,6-Dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

There total 5 articles about 6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₃₂N₂O₃Si

: 1557247-72-9
6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; acetonitrile; at 20 ℃;
DOI:10.1021/jm500550e

Reference yield:

: C₁₂H₂₀N₂O₃

: 1557247-72-9
6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; trichlorophosphate / 20 °C

1.2: 110 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: lithium hydroxide monohydrate / acetonitrile; water; tetrahydrofuran / 20 °C

With pyridine; lithium hydroxide monohydrate; sodium hydride; trichlorophosphate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm500550e

Reference yield:

: 1233243-56-5,1423716-54-4
ethyl 6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate

: 1557247-72-9
6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: lithium hydroxide monohydrate / acetonitrile; water; tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; sodium hydride; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm500550e