N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

Base Information

Chemical Name:N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester
CAS No.:204458-77-5
Molecular Formula:C₆₁H₇₀N₂O₁₁
Molecular Weight:1007.23
Hs Code.:

N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

Synonyms:N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

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Chemical Property of N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

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Technology Process of N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

There total 8 articles about N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 103-40-2
succinic acid monobenzyl ester

: (2S,3R)-2-Amino-4-benzyloxy-3-hydroxy-N-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propyl]-butyramide

: 204458-77-5
N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at -20 - 20 ℃; for 4h;
DOI:10.1016/S0968-0896(98)00245-4

Reference yield:

: 4392-24-9
Cinnamyl bromide

: 204458-77-5
N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / NaH / dimethylformamide; tetrahydrofuran / 1 h / 65 °C

2: H₂ / Pd/C / ethyl acetate / 48 h / Ambient temperature

3: TFA / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 62 percent / EDC, HOBT, NMM / CH₂Cl₂ / 5.5 h / -20 - 20 °C

5: TFA / CH₂Cl₂ / 1.5 h / 0 - 20 °C

6: 65 percent / EDC, HOBT, NMM / CH₂Cl₂ / 4 h / -20 - 20 °C

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00245-4

Reference yield:

: 1-azido-3-(tri-O-benzyl-α-L-fucopyranosyl)-2-propanol

: 204458-77-5
N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / NaH / dimethylformamide; tetrahydrofuran / 1 h / 65 °C

2: H₂ / Pd/C / ethyl acetate / 48 h / Ambient temperature

3: TFA / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 62 percent / EDC, HOBT, NMM / CH₂Cl₂ / 5.5 h / -20 - 20 °C

5: TFA / CH₂Cl₂ / 1.5 h / 0 - 20 °C

6: 65 percent / EDC, HOBT, NMM / CH₂Cl₂ / 4 h / -20 - 20 °C

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00245-4