5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine
• CAS No.: 111452-90-5
• Molecular Formula: C₂₆H₂₈N₆O₄S
• Molecular Weight: 520.612

Synonyms:5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Chemical Property of 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

There total 3 articles about 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-(4-Methoxy-3-{2-[4-(4-nitro-benzenesulfonyl)-phenylamino]-ethoxy}-benzyl)-pyrimidine-2,4-diamine (111452-85-8) → 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine (111452-90-5)

Guidance literature:

With hydrogen; Raney Ni (W₂); In methanol; 2-methoxy-ethanol; at 50 ℃; for 1.33333h; under 3750.3 Torr;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

N-(2-bromo-ethyl)-4-(4-nitro-benzenesulfonyl)-aniline (111453-05-5) → 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine (111452-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 21 percent / NaOMe / 2-methoxy-ethanol / Ambient temperature

2: 63 percent / H₂ / Raney Ni (W₂) / 2-methoxy-ethanol; methanol / 1.33 h / 50 °C / 3750.3 Torr

With hydrogen; sodium methylate; Raney Ni (W₂); In methanol; 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

2,4-diamino-5-(3-hydroxy-4-methoxybenzyl)-pyrimidine (83166-76-1) → 5-(3-{2-[4-(4-Amino-benzenesulfonyl)-phenylamino]-ethoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine (111452-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 21 percent / NaOMe / 2-methoxy-ethanol / Ambient temperature

2: 63 percent / H₂ / Raney Ni (W₂) / 2-methoxy-ethanol; methanol / 1.33 h / 50 °C / 3750.3 Torr

With hydrogen; sodium methylate; Raney Ni (W₂); In methanol; 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

upstream raw materials:

5-(4-Methoxy-3-{2-[4-(4-nitro-benzenesulfonyl)-phenylamino]-ethoxy}-benzyl)-pyrimidine-2,4-diamine

N-(2-bromo-ethyl)-4-(4-nitro-benzenesulfonyl)-aniline

2,4-diamino-5-(3-hydroxy-4-methoxybenzyl)-pyrimidine

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