5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

Base Information

Chemical Name:5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one
CAS No.:232950-93-5
Molecular Formula:C₁₉H₁₂F₆N₂O₅
Molecular Weight:462.305
Hs Code.:

Synonyms:5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

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Chemical Property of 5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

Chemical Property:

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Technology Process of 5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

There total 10 articles about 5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 232950-93-5
5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

Guidance literature:: Multi-step reaction with 12 steps

1: CrO₃; AcOH

2: SOCl₂ / CH₂Cl₂

3: tetrahydrofuran

4: Fe; aq. NH₄Cl

5: pyridine / CH₂Cl₂

6: TEA / CH₂Cl₂

7: NaN₃ / dimethylformamide / 80 °C

8: PPh₃; water / tetrahydrofuran / 55 °C

9: pyridine / CH₂Cl₂

10: TFA / CH₂Cl₂ / 20 °C

11: pyridine / dimethylformamide

With pyridine; chromium(VI) oxide; thionyl chloride; sodium azide; TEA; water; iron; ammonium chloride; acetic acid; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.021

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 232950-93-5
5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: SOCl₂ / CH₂Cl₂

2: tetrahydrofuran

3: Fe; aq. NH₄Cl

4: pyridine / CH₂Cl₂

5: TEA / CH₂Cl₂

6: NaN₃ / dimethylformamide / 80 °C

7: PPh₃; water / tetrahydrofuran / 55 °C

8: pyridine / CH₂Cl₂

9: TFA / CH₂Cl₂ / 20 °C

10: pyridine / dimethylformamide

With pyridine; thionyl chloride; sodium azide; TEA; water; iron; ammonium chloride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.021

Reference yield:

: 140373-77-9
tert-butyl 2-fluoro-4-aminobenzoate

: 232950-93-5
5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / CH₂Cl₂

2: TEA / CH₂Cl₂

3: NaN₃ / dimethylformamide / 80 °C

4: PPh₃; water / tetrahydrofuran / 55 °C

5: pyridine / CH₂Cl₂

6: TFA / CH₂Cl₂ / 20 °C

7: pyridine / dimethylformamide

With pyridine; sodium azide; TEA; water; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.021