Technology Process of 1-(5-(S)-amino-6-azidohexyl)-3-o-tolylurea
There total 6 articles about 1-(5-(S)-amino-6-azidohexyl)-3-o-tolylurea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
for 15h;
Ambient temperature;
DOI:10.1021/jm00017a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / 1 N aq. NaOH / 15 h
2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et2O, RT, 24 h
3: 46 percent / DMAP, triethylamine / CH2Cl2 / 2.25 h / Ambient temperature
4: 69 percent / sodium azide / dimethylformamide / 1.5 h / 80 °C
5: 100 percent / 4 N HCl / dioxane / 15 h / Ambient temperature
With
hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / 1 N aq. NaOH / 15 h
2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et2O, RT, 24 h
3: 46 percent / DMAP, triethylamine / CH2Cl2 / 2.25 h / Ambient temperature
4: 69 percent / sodium azide / dimethylformamide / 1.5 h / 80 °C
5: 100 percent / 4 N HCl / dioxane / 15 h / Ambient temperature
With
hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022
