1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

Base Information

Chemical Name:1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea
CAS No.:1442473-63-3
Molecular Formula:C₂₄H₁₉Cl₂F₂N₅O₂
Molecular Weight:518.35
Hs Code.:

Synonyms:1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

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Chemical Property of 1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

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Technology Process of 1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

There total 14 articles about 1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1442473-62-2
1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

: 1442473-63-3
1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 20 ℃; for 3h;

Reference yield:

: 1012878-91-9
3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442473-63-3
1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: 200 °C / Sealed tube

2: sodium hydrogencarbonate / ethyl acetate / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

4: trifluoroacetic acid; methoxybenzene / 3 h / 20 °C

With sodium hydrogencarbonate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethyl acetate;

Reference yield:

: 1442470-43-0
7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442473-63-3
1-(4-chloro-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethyl acetate / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

3: trifluoroacetic acid; methoxybenzene / 3 h / 20 °C

With sodium hydrogencarbonate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethyl acetate;