Technology Process of (6S,9aS)-2-allyl-N-benzyl-6-(4-hydroxybenzyl)-8-((1-methyl-3-(6-(3-phenylureido)pyridine-3-yl)-1H-indol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]-triazine-1-carboxamide
There total 13 articles about (6S,9aS)-2-allyl-N-benzyl-6-(4-hydroxybenzyl)-8-((1-methyl-3-(6-(3-phenylureido)pyridine-3-yl)-1H-indol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]-triazine-1-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
1.2: 2 h / 20 °C
2.1: toluene-4-sulfonic acid / toluene / 0.5 h / 80 °C
3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 80 °C / Reflux
4.1: triethylamine / dichloromethane / 18 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 5 h
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide
2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 10 - 20 °C
3.1: acetic acid / methanol / 4 h / 20 °C
3.2: 1 h / 20 °C
4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
4.2: 3 h
5.1: piperidine / dichloromethane
6.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
6.2: 2 h / 20 °C
7.1: toluene-4-sulfonic acid / toluene / 0.5 h / 80 °C
8.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 80 °C / Reflux
9.1: triethylamine / dichloromethane / 18 h / 20 °C
10.1: trifluoroacetic acid / dichloromethane / 5 h
With
piperidine; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); iodine; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; potassium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
