(2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide

Base Information

• Chemical Name: (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide
• CAS No.: 854739-95-0
• Molecular Formula: C₃₆H₄₈N₆O₆S
• Molecular Weight: 692.88
• Mol file: 854739-95-0.mol

Synonyms:(2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide

Chemical Property of (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide

There total 12 articles about (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S)-3-Methyl-2-(2-oxo-3-pyridin-3-ylmethyl-imidazolidin-1-yl)-pentanoic acid tert-butyl ester + N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(E-hydroxyiminomethyl)-N-(isobutyl)benzenesulfonamide (890904-63-9) → (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide (854739-95-0)

Guidance literature:

(2S,3S)-3-Methyl-2-(2-oxo-3-pyridin-3-ylmethyl-imidazolidin-1-yl)-pentanoic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(E-hydroxyiminomethyl)-N-(isobutyl)benzenesulfonamide; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2006.02.013

Reference yield:

N-(2-aminoethyl)-L-isoleucine tert-butyl ester (854745-37-2) → (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide (854739-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: MgSO₄ / CH₂Cl₂ / 2 h / 20 °C

2.1: sodium borohydride / methanol / 1 h / 20 °C

3.1: dimethylformamide / Heating

4.1: trifluoroacetic acid / CH₂Cl₂ / 20 °C

4.2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxybenzotriazole; ethyldiisopropylamine / dimethylformamide / 20 °C

With sodium tetrahydroborate; magnesium sulfate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.02.013

Reference yield:

(2S,3S)-3-Methyl-2-(2-{[1-pyridin-3-yl-meth-(E)-ylidene]-amino}-ethylamino)-pentanoic acid tert-butyl ester → (2S,3S)-3-methyl-2-[2-oxo-3-pyridin-3-ylmethylimidazolidin-1-yl]pentanoic acid ((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(E-hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)amide (854739-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium borohydride / methanol / 1 h / 20 °C

2.1: dimethylformamide / Heating

3.1: trifluoroacetic acid / CH₂Cl₂ / 20 °C

3.2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxybenzotriazole; ethyldiisopropylamine / dimethylformamide / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.02.013

upstream raw materials:

N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(E-hydroxyiminomethyl)-N-(isobutyl)benzenesulfonamide

N-(2-aminoethyl)-L-isoleucine tert-butyl ester

Tert-butyl (2S,3S)-2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino}-3-methylpentanoate

((1S,2R)-1-benzyl-2-hydroxy-3-{[4-(hydroxyiminomethyl)benzenesulfonyl](isobutyl)amino}propyl)carbamic acid tert-butyl ester