2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran
• CAS No.: 1610613-72-3
• Molecular Formula: C₂₂H₄₄O₂
• Molecular Weight: 340.59
• Mol file: 1610613-72-3.mol

Synonyms:2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran

Chemical Property of 2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran

There total 1 articles about 2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-bromononan-1-ol (55362-80-6) → 2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran (1610613-72-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane

2.1: sodium hydride; diisopropylamine / paraffin oil; tetrahydrofuran / 0 - 60 °C / Inert atmosphere

2.2: 1.3 h / -10 - 30 °C / Inert atmosphere

2.3: 12 h / 28 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux

4.1: triethylamine / chloroform / 12 h / 20 °C / Cooling with ice

5.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; paraffin oil;

DOI:10.1002/jlcr.3504

Reference yield:

2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran (1610613-72-3) → 1-O-benzyl-3-O-(heptadec-16-en-1-yl)-2-O-[(10RS)-10-methylhexadecyl]-sn-glycerol (1610613-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; bromine / dichloromethane / 0 - 20 °C

2.1: potassium hydride / toluene / 20 h / 20 °C / Inert atmosphere

2.2: 12 h / Reflux; Inert atmosphere

With bromine; potassium hydride; triphenylphosphine; In dichloromethane; toluene;

DOI:10.1039/c4ob00048j

Reference yield:

2-{[(10RS)-10-methylhexadecyl]oxy}tetrahydro-2H-pyran (1610613-72-3) → 1-O-benzyl-3-O-[(10RS)-10-methylheptadec-16-en-1-yl]-2-O-[(10RS)-methylhexadecyl]-sn-glycerol (1610613-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; bromine / dichloromethane / 0 - 20 °C

2.1: potassium hydride / toluene / 20 h / 20 °C / Inert atmosphere

2.2: 12 h / Reflux; Inert atmosphere

With bromine; potassium hydride; triphenylphosphine; In dichloromethane; toluene;

DOI:10.1039/c4ob00048j

upstream raw materials:

9-bromononan-1-ol

Downstream raw materials:

1-O-benzyl-3-O-(heptadec-16-en-1-yl)-2-O-[(10RS)-10-methylhexadecyl]-sn-glycerol

1-O-benzyl-3-O-[(10RS)-10-methylheptadec-16-en-1-yl]-2-O-[(10RS)-methylhexadecyl]-sn-glycerol

3,3′-O,O-(dotriacontane-1,32-diyl)bis{2-O-[(10RS)-10-methylhexadecyl]-sn-glycerol}

(10RS)-10-methylhexadecanoic acid