(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

Base Information

Chemical Name:(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol
CAS No.:173537-01-4
Molecular Formula:C₃₅H₄₈O₆Si
Molecular Weight:592.848
Hs Code.:

Synonyms:(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

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Chemical Property of (E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

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Technology Process of (E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

There total 13 articles about (E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 173537-00-3
(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-1-tetrahydropyranyloxy-tetradeca-3,10,12-triene

: 173537-01-4
(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In isopropyl alcohol; for 1h; Heating;

Reference yield:

: 173536-84-0
(E,E)-8-tert-butyldiphenylsiloxy-1,1-bis(methoxycarbonyl)-4,6-octadiene

: 173537-01-4
(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) KI / 1.) DMF, 1 h, 35-40 deg C, 2.) DMF, THF, 70 deg C, 12 h

2: 90 percent / pyridinium p-toluenesulfonate / propan-2-ol / 1 h / Heating

With pyridinium p-toluenesulfonate; sodium hydride; potassium iodide; In isopropyl alcohol;

Reference yield:

: 149311-09-1
(2E,4E)-7-(Tetrahydro-pyran-2-yloxy)-hepta-2,4-dien-1-ol

: 173537-01-4
(E,E,E)-3-methyl-14-tert-butyldiphenylsiloxy-7,7-bis(methoxycarbonyl)-tetradeca-3,10,12-trien-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / tetrahydrofuran / 1 h / Ambient temperature

2: pyridinium-p-toluenesulfonate / propan-2-ol / 1 h / Heating

3: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 1.) NaH, 2.) KI / 1.) DMF, room t., 2.) DMF, THF, 70-75 deg C, 15 h

5: 1.) NaH, 2.) KI / 1.) DMF, 1 h, 35-40 deg C, 2.) DMF, THF, 70 deg C, 12 h

6: 90 percent / pyridinium p-toluenesulfonate / propan-2-ol / 1 h / Heating

With 1H-imidazole; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;