N⁶-(2′-aminobiphenyl-4-ylmethyl)-N²-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine

Base Information

• Chemical Name: N⁶-(2′-aminobiphenyl-4-ylmethyl)-N²-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine
• CAS No.: 1448338-05-3
• Molecular Formula: C₂₉H₃₆N₈
• Molecular Weight: 496.658

Synonyms:N⁶-(2′-aminobiphenyl-4-ylmethyl)-N²-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine

Chemical Property of N⁶-(2′-aminobiphenyl-4-ylmethyl)-N²-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine

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Technology Process of N⁶-(2′-aminobiphenyl-4-ylmethyl)-N²-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine

There total 5 articles about N⁶-(2′-aminobiphenyl-4-ylmethyl)-N²-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-benzeneboronic acid hydrochloride + N2-(4-aminocyclohexyl)-N6-(4-bromobenzyl)-9-cyclopentyl-9H-purine-2,6-diamine (1448338-03-1) → N6-(2′-aminobiphenyl-4-ylmethyl)-N2-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine (1448338-05-3)

Guidance literature:

With sodium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 65h; Inert atmosphere; Sealed tube;

Reference yield: 85.0%

N2-(4-aminocyclohexyl)-N6-(4-bromobenzyl)-9-cyclopentyl-9H-purine-2,6-diamine (1448338-03-1) + 2-aminophenylboronic acid (5570-18-3) → N6-(2′-aminobiphenyl-4-ylmethyl)-N2-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine (1448338-05-3)

Guidance literature:

With potassium phosphate tribasic trihydrate; tetrabutylammomium bromide; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1021/jm4006884

Reference yield:

9-(cyclopentyl)-2,6-(dichloro)-9H-purine (211733-67-4) → N6-(2′-aminobiphenyl-4-ylmethyl)-N2-(4-aminocyclohexyl)-9-cyclopentyl-9H-purine-2,6-diamine (1448338-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / propan-1-ol / 4 h / 120 °C / Sealed tube; Inert atmosphere

2: 12 h / 160 °C / Sealed tube; Inert atmosphere

3: potassium phosphate tribasic trihydrate; palladium diacetate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 6 h / 80 °C / Sealed tube; Inert atmosphere

With potassium phosphate tribasic trihydrate; tetrabutylammomium bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; In propan-1-ol; N,N-dimethyl-formamide;

DOI:10.1021/jm4006884

upstream raw materials:

N²-(4-aminocyclohexyl)-N⁶-(4-bromobenzyl)-9-cyclopentyl-9H-purine-2,6-diamine

2-aminophenylboronic acid

9-(cyclopentyl)-2,6-(dichloro)-9H-purine

2,6 dichloropurine

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