(R)-2-HYDROXYBUTYL TOSYLATE

Base Information

• Chemical Name: (R)-2-HYDROXYBUTYL TOSYLATE
• CAS No.: 143693-24-7
• Molecular Formula: C11H16 O4 S
• Molecular Weight: 244.312
• Mol file: 143693-24-7.mol

Synonyms:(R)-2-HYDROXYBUTYL TOSYLATE

Chemical Property of (R)-2-HYDROXYBUTYL TOSYLATE

Chemical Property:

• PSA: 71.98000
• LogP: 2.55200

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-HYDROXYBUTYL TOSYLATE

There total 3 articles about (R)-2-HYDROXYBUTYL TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-toluenesulfonyl chloride (98-59-9) + 1,2-dihydroxybutane (584-03-2) → (R/S)-1,2-Butandiol-1-<(4-methylbenzol)sulfonat> (143693-24-7)

Guidance literature:

With di(n-butyl)tin oxide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2010.09.008

Reference yield: 14.0%

p-toluenesulfonyl chloride (98-59-9) + 1,2-dihydroxybutane (584-03-2) → (R/S)-1,2-Butandiol-1-<(4-methylbenzol)sulfonat> (143693-24-7) + Toluene-4-sulfonic acid 1-hydroxymethyl-propyl ester + 1,2-Bis(4-toluenesulfonyloxy)butane (185215-29-6)

Guidance literature:

With pyridine; In dichloromethane; at -10 ℃; for 5h; Title compound not separated from byproducts;

Reference yield:

trans-2-(p-Toluenesulfonyloxymethyl)-3-methyloxirane (19300-58-4,107033-47-6,121157-12-8,141783-42-8) → (R/S)-1,2-Butandiol-1-<(4-methylbenzol)sulfonat> (143693-24-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; magnesium iodide; Yield given. Multistep reaction; 1.) toluene, ether, -60 deg C, 2.) 70 deg C, 1 h;

DOI:10.1021/jo00120a025

upstream raw materials:

p-toluenesulfonyl chloride

1,2-dihydroxybutane

trans-2-(p-Toluenesulfonyloxymethyl)-3-methyloxirane

Downstream raw materials:

C₁₆H₂₂O₆S

4-[1-(4-toluenesulfonyloxy)but-2-yloxy]-6-methyl-2-pyrone

(S)-(-)-2-hydroxybutyl tosylate

2-butanoyloxybutyl p-toluenesulfonate