4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Base Information

Chemical Name:4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid
CAS No.:1446236-18-5
Molecular Formula:C₂₂H₁₆F₂N₂O₆S
Molecular Weight:474.442
Hs Code.:

Synonyms:4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

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Chemical Property of 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

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Technology Process of 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

There total 14 articles about 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1446236-17-4
ethyl 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1 H-pyrrolo[2,3-c]pyridine-2-carboxylate

: 1446236-18-5
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 90 ℃; for 3h;
DOI:10.1021/acs.jmedchem.0c00628

Reference yield:

: 1446236-15-2
ethyl 1-benzyl-6-methyl-7-oxo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

: 1446236-18-5
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.5 h / Inert atmosphere

1.2: 16 h / 60 °C

2.1: trifluoroacetic acid; sulfuric acid; methoxybenzene / 4 h / 90 °C

3.1: water; lithium hydroxide / 1,4-dioxane / 2 h / 65 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; water; methoxybenzene; trifluoroacetic acid; lithium hydroxide; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In 1,4-dioxane;

Reference yield:

: 1445994-61-5
ethyl 1-benzyl-4-bromo-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

: 1446236-18-5
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.5 h / Inert atmosphere

2.2: 16 h / 60 °C

3.1: trifluoroacetic acid; sulfuric acid; methoxybenzene / 4 h / 90 °C

4.1: water; lithium hydroxide / 1,4-dioxane / 2 h / 65 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; water; potassium acetate; methoxybenzene; trifluoroacetic acid; lithium hydroxide; XPhos; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In 1,4-dioxane;