(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

Base Information

Chemical Name:(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt
CAS No.:1333379-75-1
Molecular Formula:C₂₄H₂₂ClF₃NO₄*K
Molecular Weight:519.989
Hs Code.:

Synonyms:(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

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Chemical Property of (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

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Technology Process of (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

There total 15 articles about (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215119-43-9
(R)-2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

: 1333379-75-1
(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; water; acetone; at 35 - 60 ℃; for 24h;

Reference yield:

: 37033-95-7
5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 1333379-75-1
(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / tetrahydrofuran / 19.5 h / 20 - 34 °C / Inert atmosphere; Reflux

2.1: water; acetic acid / 40 h / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 18.17 h / 20 - 29 °C / Inert atmosphere

4.1: tert-butyl alcohol; copper(II) acetate monohydrate / (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / tetrahydrofuran / 17 h / 5 - 10 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate; water

5.2: 3.5 h / 2585.81 Torr / Parr shaker

6.1: caesium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

7.1: N-chloro-succinimide / dichloromethane / 0.83 h / -5 °C

8.1: sodium hydroxide; methanol / 1,4-dioxane; water / 17 h / 20 °C

9.1: potassium hydroxide / water; tetrahydrofuran; acetone / 24 h / 35 - 60 °C

With hydrogenchloride; methanol; N-chloro-succinimide; potassium tert-butylate; water; copper(II) acetate monohydrate; caesium carbonate; acetic acid; potassium hydroxide; sodium hydroxide; tert-butyl alcohol; (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1333379-86-4
potassium 7-(benzyloxy)-2-(ethoxycarbonyl)-3H-pyrrolo[1,2-a]indol-1-olate

: 1333379-75-1
(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid potassium salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; acetic acid / 40 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 18.17 h / 20 - 29 °C / Inert atmosphere

3.1: tert-butyl alcohol; copper(II) acetate monohydrate / (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / tetrahydrofuran / 17 h / 5 - 10 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water

4.2: 3.5 h / 2585.81 Torr / Parr shaker

5.1: caesium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

6.1: N-chloro-succinimide / dichloromethane / 0.83 h / -5 °C

7.1: sodium hydroxide; methanol / 1,4-dioxane; water / 17 h / 20 °C

8.1: potassium hydroxide / water; tetrahydrofuran; acetone / 24 h / 35 - 60 °C

With hydrogenchloride; methanol; N-chloro-succinimide; potassium tert-butylate; water; copper(II) acetate monohydrate; caesium carbonate; acetic acid; potassium hydroxide; sodium hydroxide; tert-butyl alcohol; (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;