4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

Base Information

Chemical Name:4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline
CAS No.:1363363-31-8
Molecular Formula:C₁₉H₂₂N₄OS
Molecular Weight:354.476
Hs Code.:

Synonyms:4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

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Chemical Property of 4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

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Technology Process of 4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

There total 11 articles about 4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3-methyl-5-((4-(5-(4-nitrophenyl)thiazol-2-yl)cyclohexyl)methyl)-1,2,4-oxadiazole

: 1363363-31-8
4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

Guidance literature:: With sodium sulfide; In 1,4-dioxane; water; at 80 - 85 ℃; for 1h;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1363363-31-8
4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine / aluminum (III) chloride / 0.67 h

2.1: hexamethylenetetramine / dichloromethane / 1 h

2.2: 51 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

4.1: Lawessons reagent / 1,4-dioxane / 3 h / 55 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

6.1: oxalyl dichloride / 1,2-dichloro-ethane / 16 h / 20 °C

6.2: 16 h / 20 °C

7.1: N,N-dimethyl-formamide / 3 h / 120 °C / Microwave

8.1: sodium sulfide / 1,4-dioxane; water / 1 h / 80 - 85 °C

With Lawessons reagent; sodium sulfide; oxalyl dichloride; hexamethylenetetramine; water; bromine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; aluminum (III) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 874-61-3
4-oxocyclohexanecarboxylic acid

: 1363363-31-8
4-(2-(4-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclohexyl)thiazol-5-yl)aniline

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium ethanolate / ethanol / 4 - 5 °C / Inert atmosphere

1.2: pH 5

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.75 h / 30 - 50 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

4.1: Lawessons reagent / 1,4-dioxane / 3 h / 55 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

6.1: oxalyl dichloride / 1,2-dichloro-ethane / 16 h / 20 °C

6.2: 16 h / 20 °C

7.1: N,N-dimethyl-formamide / 3 h / 120 °C / Microwave

8.1: sodium sulfide / 1,4-dioxane; water / 1 h / 80 - 85 °C

With Lawessons reagent; sodium sulfide; oxalyl dichloride; water; ammonium formate; sodium ethanolate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;