7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

Base Information

Chemical Name:7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol
CAS No.:1422643-50-2
Molecular Formula:C₂₀H₃₄N₄O₄SSi
Molecular Weight:454.666
Hs Code.:

Synonyms:7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

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Chemical Property of 7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

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Technology Process of 7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

There total 10 articles about 7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1422643-30-8
7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-heptan-2-ol

: 1422643-50-2
7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 6h;
DOI:10.1016/j.tet.2012.12.076

Reference yield:

: 118794-69-7
6-[(tert-butyldimethylsilyl)oxy]hexanal

: 1422643-50-2
7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -40 °C

1.2: -40 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

3.1: (S,S)-(salen)cobalt(III)(OAc); water / 14 h / 0 °C

4.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 2 h / 20 °C

5.1: potassium carbonate / methanol / 2.5 h / 20 °C

6.1: montmorillonite K-10 clay / dichloromethane / 6 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 °C

With n-butyllithium; (S,S)-(salen)cobalt(III)(OAc); water; di(n-butyl)tin oxide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; 1.2: |Wittig Olefination;
DOI:10.1016/j.tet.2012.12.076

Reference yield:

: 166194-76-9
tert-butyl-(hept-6-enyloxy)-dimethyl-silane

: 1422643-50-2
7-(tert-butyl-dimethyl-silanyloxy)-1-(1-phenyl-1H-tetrazole-5-sulfonyl)-heptan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

2: (S,S)-(salen)cobalt(III)(OAc); water / 14 h / 0 °C

3: di(n-butyl)tin oxide; triethylamine / dichloromethane / 2 h / 20 °C

4: potassium carbonate / methanol / 2.5 h / 20 °C

5: montmorillonite K-10 clay / dichloromethane / 6 h / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 °C

With (S,S)-(salen)cobalt(III)(OAc); water; di(n-butyl)tin oxide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1016/j.tet.2012.12.076