3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

Base Information

Chemical Name:3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid
CAS No.:1445879-90-2
Molecular Formula:C₂₄H₂₄BrN₃O₄S
Molecular Weight:530.442
Hs Code.:

Synonyms:3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

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Chemical Property of 3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

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Technology Process of 3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

There total 6 articles about 3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1374868-46-8
3-amino-5-cyclopentylbenzoic acid

: 1445879-89-9
7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

: 1445879-90-2
3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

Guidance literature:: With acetic acid; at 20 ℃;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-90-2
3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: acetic acid / 20 °C

With chlorosulfonic acid; acetic acid; triethylamine; trichlorophosphate; In dichloromethane;

Reference yield:

: 850036-28-1
cyclopenten-1-ylboronic acid

: 1445879-90-2
3-({7-bromo-3-[(cyclopropylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / 145 °C / Microwave irradiation

1.2: Inert atmosphere

2.1: acetic acid / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water;