3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

Base Information

Chemical Name:3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide
CAS No.:177478-46-5
Molecular Formula:C₂₀H₁₉BrCl₂N₄O₃
Molecular Weight:514.206
Hs Code.:

Synonyms:3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

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Chemical Property of 3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

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Technology Process of 3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

There total 5 articles about 3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.3%

: 177478-45-4
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[2,4-dichloro-3-(hydroxymethyl)methylanilino]-2-oxoethyl}-2-propenamide

: 177478-46-5
3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/jm030326t

Reference yield:

: 177477-90-6
3-(N-Glycyl-N-methylamino)-1-(tert-butyldiphenyl-silyloxymethyl)-2,6-dichlorobenzene

: 177478-46-5
3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

Guidance literature:: Multi-step reaction with 3 steps

1: 75.4 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h / 20 °C

2: 92.4 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: 63.3 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 5 h / 20 °C

With carbon tetrabromide; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030326t

Reference yield:

: 160648-18-0
(E)-3-(6-acetylamino-pyridin-3-yl)acrylic acid

: 177478-46-5
3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyl bromide

Guidance literature:: Multi-step reaction with 3 steps

1: 75.4 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h / 20 °C

2: 92.4 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: 63.3 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 5 h / 20 °C

With carbon tetrabromide; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030326t