(2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

Base Information

Chemical Name:(2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane
CAS No.:153109-02-5
Molecular Formula:C₂₈H₄₀O₃Si
Molecular Weight:452.709
Hs Code.:

Synonyms:(2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

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Chemical Property of (2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

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Technology Process of (2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

There total 12 articles about (2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 152033-08-4
(2S,3S,5R,6S,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-5-(phenylsulfonyl)-1,7-dioxaspiro<5.5>undecane

: 153109-02-5
(2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

Guidance literature:: With Raney Ni (W-2); In ethanol; Heating;
DOI:10.1016/S0040-4039(00)74091-3

Reference yield:

: 1-Hydroxy-9-(methoxymethoxy)-4,8-dimethyl-10-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6-(phenylsulfonyl)-5-decanone

: 153109-02-5
(2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / TMSBr / CH₂Cl₂ / 1.) -30 to 3 deg C, 2 h, 2.) 3 deg C, 7 h

2: 88 percent / Raney-Ni W-2 / ethanol / 22 h / Heating

With trimethylsilyl bromide; Raney-Ni W-2; In ethanol; dichloromethane;
DOI:10.1021/jo00121a026

Reference yield:

: 73746-79-9,80698-15-3,107242-87-5,10603-03-9,823-22-3
α-methyl-δ-valerolactone

: 153109-02-5
(2S,3S,6R,11R)-3,11-Dimethyl-2-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,7-dioxaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-BuLi / 1) ether, hexane, -78 deg C

2: 88 percent / bromotrimethylsilane / CH₂Cl₂ / -40 - 0 °C

3: 88 percent / Raney Ni (W-2) / ethanol / Heating

With n-butyllithium; trimethylsilyl bromide; Raney Ni (W-2); In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)74091-3