3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide

Base Information

• Chemical Name: 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide
• CAS No.: 1443991-55-6
• Molecular Formula: C₁₇H₁₇O₃P
• Molecular Weight: 300.294
• Mol file: 1443991-55-6.mol

Synonyms:3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide

Chemical Property of 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide

There total 4 articles about 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-Phenylprop-1-yne (673-32-5) + ethyl hydrogen phenylphosphonate (4546-19-4) → 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide (1443991-55-6)

Guidance literature:

With potassium hexafluorophosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; silver(I) acetate; silver carbonate; In tert-butyl alcohol; at 90 ℃; for 30h;

DOI:10.1021/jo401608v

Reference yield: 93.0%

→ 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide (1443991-55-6)

Guidance literature:

With potassium hexafluorophosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; silver(I) acetate; silver carbonate; In tert-butyl alcohol; for 30h;

Reference yield:

1-Phenylprop-1-yne (673-32-5) + ethyl hydrogen phenylphosphonate (4546-19-4) → 3-phenyl-4-methyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide (1443991-55-6) + 4-phenyl-3-methyl-1-ethoxybenz[c-1,2]oxaphosphinine 1-oxide

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; silver carbonate; In tert-butyl alcohol; at 90 ℃; for 4h; Overall yield = 91 %; regioselective reaction;

DOI:10.1002/chem.201302652

upstream raw materials:

1-Phenylprop-1-yne

ethyl hydrogen phenylphosphonate

diethyl phenylphosphonate