(7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine

Base Information

• Chemical Name: (7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine
• CAS No.: 667870-43-1
• Molecular Formula: C₂₉H₂₆N₄O
• Molecular Weight: 446.552
• Mol file: 667870-43-1.mol

Synonyms:(7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine

Chemical Property of (7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine

There total 1 articles about (7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + hexanedial (1072-21-5) + (S)-l-(α-aminobenzyl)-2-naphthol (R,R)-tartrate (219897-70-8,219897-36-6) → (7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine (667870-43-1)

Guidance literature:

In dichloromethane; at -5 - 0 ℃; for 5h;

DOI:10.1055/s-2003-43353

Reference yield: 93.0%

(7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine (667870-43-1) → (S)-1-(α-azepanylbenzyl)-2-naphthol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -5 ℃; for 1h;

DOI:10.1016/j.tetasy.2003.12.025

Reference yield:

(7aR,12R,14S)-12-(1-benzotriazolyl)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho[1',2':5,6][1,3]oxazino[2,1-b]azepine (667870-43-1) → (7aR,14S)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho-[1',2':5,6][1,3]oxazino[2,1-b]azepine (500352-90-9)

Guidance literature:

With sodium cyanoborohydride; In methanol; dichloromethane; at 20 ℃;

DOI:10.1055/s-2003-43353

upstream raw materials:

1,2,3-Benzotriazole

hexanedial

(S)-l-(α-aminobenzyl)-2-naphthol (R,R)-tartrate

Downstream raw materials:

(7aR,14S)-14-phenyl-7a,8,9,10,11,12-hexahydro-14H-naphtho-[1',2':5,6][1,3]oxazino[2,1-b]azepine