(3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

Base Information

Chemical Name:(3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione
CAS No.:1082605-49-9
Molecular Formula:C₁₉H₂₅NO₂S
Molecular Weight:331.479
Hs Code.:

Synonyms:(3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

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Chemical Property of (3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

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Technology Process of (3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

There total 23 articles about (3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1082605-50-2
(3R,1′S,4″S)-1-benzyl-3-[2-bromo-1-(2,2-dimethyl-1,3-dioxolan-4-yl)allyl]pyrrolidine-2-thione

: 1082605-49-9
(3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

Guidance literature:: With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In tetrahydrofuran; Reflux;
DOI:10.1055/s-2008-1078030

Reference yield: 38.0%

: 17642-88-5
1-benzyl-2-pyrrolidinethione

: 198402-59-4
(S,E)-4-(3-bromoprop-1-en-1-yl)-2,2-dimethyl-1,3-dioxolane

: 1082605-47-7
(3S,1′R,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)allyl]pyrrolidine-2-thione

: 1082605-51-3
(3S,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)allyl]-pyrrolidine-2-thione

: 1082605-49-9
(3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

Guidance literature:: 1-benzyl-2-pyrrolidinethione; (S,E)-4-(3-bromoprop-1-en-1-yl)-2,2-dimethyl-1,3-dioxolane; In acetonitrile; for 96h; Molecular sieve; Inert atmosphere;

With triethylamine; In acetonitrile; at 35 - 40 ℃; for 7h; diastereoselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1039/c3ob41580e

Reference yield: 38.0%

: 17642-88-5
1-benzyl-2-pyrrolidinethione

: C₈H₁₃BrO₂

: 1082605-47-7
(3S,1′R,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)allyl]pyrrolidine-2-thione

: 1082605-51-3
(3S,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)allyl]-pyrrolidine-2-thione

: 1082605-49-9
(3R,1′S,4″S)-1-benzyl-3-[1-(2,2-dimethyl-1,3-dioxolan-4-yl)-allyl]pyrrolidine-2-thione

Guidance literature:: 1-benzyl-2-pyrrolidinethione; C₈H₁₃BrO₂; In acetonitrile;

With triethylamine; In acetonitrile; at 35 ℃;
DOI:10.1055/s-2008-1078030