3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

Base Information

Chemical Name:3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester
CAS No.:120130-17-8
Molecular Formula:C₂₇H₂₅F₃N₄O₁₀
Molecular Weight:622.512
Hs Code.:

Synonyms:3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

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Chemical Property of 3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

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Technology Process of 3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

There total 6 articles about 3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 120130-12-3
4-methoxy-3-<(2-methoxypyridin-4-yl)methyl>phenol

: 105189-50-2
3,5-dinitro-N-(trifluoroacetyl)-L-tyrosine ethyl ester

: 120130-17-8
3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

Guidance literature:: With methanesulfonyl chloride; In pyridine; for 1.16667h; Heating;
DOI:10.1039/P19880003085

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 120130-17-8
3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / di-isopropylamine, butyl-lithium / hexane; tetrahydrofuran / -70 deg C, 1.25 h, 0 deg C

2: 67 percent / butyl-lithium, 2.) water / hexane; tetrahydrofuran / -70 deg C, 0.5 h, -65 deg C

3: pyridine / 100 °C

4: 75 percent / H₂ / 10percent Pd/C, 10 M HCl / acetic acid; H₂O / 1.5 h / 2585.7 Torr

5: 37 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

With pyridine; n-butyllithium; water; hydrogen; methanesulfonyl chloride; diisopropylamine; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 120130-17-8
3'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-3,5-dinitro-N-trifluoroacetyl-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / di-isopropylamine, butyl-lithium / hexane; tetrahydrofuran / -70 deg C, 1.25 h, 0 deg C

2: 67 percent / butyl-lithium, 2.) water / hexane; tetrahydrofuran / -70 deg C, 0.5 h, -65 deg C

3: pyridine / 100 °C

4: 75 percent / H₂ / 10percent Pd/C, 10 M HCl / acetic acid; H₂O / 1.5 h / 2585.7 Torr

5: 37 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

With pyridine; n-butyllithium; water; hydrogen; methanesulfonyl chloride; diisopropylamine; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085