(R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:(R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
CAS No.:1408055-32-2
Molecular Formula:C₂₁H₁₆F₃N₃S
Molecular Weight:399.439
Hs Code.:

Synonyms:(R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Chemical Property:

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Technology Process of (R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

There total 5 articles about (R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine hydrochloride

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1408055-32-2
(R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2012.08.090

Reference yield:

: 14080-50-3
thieno[2,3-d]pyrimidin-4(3H)one

: 1408055-32-2
(R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; bromine / 3 h / 80 °C

2: trichlorophosphate / 3 h / 120 °C

3: butan-1-ol / 15 h / 145 °C

4: hydrogenchloride / diethyl ether / 29 h / -18 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3 h / 110 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; diethyl ether; water; butan-1-ol; 5: |Suzuki Coupling;
DOI:10.1016/j.tet.2012.08.090

Reference yield:

: 56844-40-7
6-bromothieno[2,3-d]pyrimidin-4(3H)-one

: 1408055-32-2
(R)-N-(1-phenylethyl)-6-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / 120 °C

2: butan-1-ol / 15 h / 145 °C

3: hydrogenchloride / diethyl ether / 29 h / -18 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3 h / 110 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trichlorophosphate; In 1,4-dioxane; diethyl ether; water; butan-1-ol; 4: |Suzuki Coupling;
DOI:10.1016/j.tet.2012.08.090