(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

Base Information

Chemical Name:(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide
CAS No.:1469979-78-9
Molecular Formula:C₁₇H₁₅F₃N₂O₂
Molecular Weight:336.314
Hs Code.:

Synonyms:(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

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Chemical Property of (rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

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Technology Process of (rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

There total 3 articles about (rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1469979-75-6
(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetic acid hydrochloride

: 1469979-78-9
(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

Guidance literature:: (rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetic acid hydrochloride; With triethylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

With ammonium hydroxide; In water; N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1469979-73-4
(rac)-tert-butyl 2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetate

: 1469979-78-9
(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1469979-59-6
(rac)-4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

: 1469979-78-9
(rac)-2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3.2: 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;