1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Base Information

• Chemical Name: 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one
• CAS No.: 168464-59-3
• Molecular Formula: C₁₈H₂₁N₅O₂S
• Molecular Weight: 371.463
• Mol file: 168464-59-3.mol

Synonyms:1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Chemical Property of 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

There total 8 articles about 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.5%

1-Ethyl-3-methyl-6-(5-cyano-2-propoxyphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-58-2) → 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-59-3)

Guidance literature:

With O,S-diethyl-dithiophosphoric acid; water; for 24h; Ambient temperature;

DOI:10.1021/jm950812j

Reference yield:

O,O-Diethyl hydrogen phosphorodithioate (298-06-6) + 1-Ethyl-3-methyl-6-(5-cyano-2-propoxyphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-58-2) → 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-59-3)

Guidance literature:

In water;

Reference yield:

2-propoxybenzoyl chloride (54090-36-7) → 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-59-3)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / a) RT, b) 45 deg C

2: aq. NaOH, 30percent H₂O₂ / 90 °C

3: 81 percent / Br₂, AcOH / 10 h / 100 °C

4: 46 percent / 18-crown-6, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran; ethanol / 4 h / Heating

5: 62.5 percent / 85percent diethyl dithiophosphate, H₂O / 24 h / Ambient temperature

With pyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; O,S-diethyl-dithiophosphoric acid; water; dihydrogen peroxide; bromine; acetic acid; In tetrahydrofuran; ethanol;

DOI:10.1021/jm950812j

upstream raw materials:

1-Ethyl-3-methyl-6-(5-cyano-2-propoxyphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

2-propoxybenzoyl chloride

5-amino-4-cyano-3-methyl-1-ethyl-(1H)-pyrazole

1-Ethyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one