Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl-

Base Information

Chemical Name:Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl-
CAS No.:143430-53-9
Molecular Formula:C₁₆H₁₇ClN₄O₄
Molecular Weight:364.788
Hs Code.:
Mol file:143430-53-9.mol

Synonyms:Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl-

Suppliers and Price of Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl-

Chemical Property:

PSA：88.24000
LogP:1.24480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl-

There total 11 articles about Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-3,8-dihydro-5,10-dimethoxy-3,7,8-trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 149552-39-6
2-Acetylamino-5-(2-chloro-acetylamino)-3,6-dimethoxy-N¹,N⁴-dimethyl-terephthalamide

: 143430-53-9
2-(chloromethyl)-5,10-dimethoxy-3,7,8-trimethylpyrimido<4,5-g>quinazoline-4,9(3H,8H)-dione

Guidance literature:: With sulfuric acid; In acetic acid; at 100 ℃; for 4h;
DOI:10.1021/jo00047a017

Reference yield:

: 5628-41-1
3,6-dicyano-1,4-dimethoxy-2-nitrobenzene

: 143430-53-9
2-(chloromethyl)-5,10-dimethoxy-3,7,8-trimethylpyrimido<4,5-g>quinazoline-4,9(3H,8H)-dione

Guidance literature:: Multi-step reaction with 10 steps

1: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C

2: 73 percent / conc. sulfuric acid, aq. sodium nitrite / 70 °C

3: 75 percent / conc. sulfuric acid / Heating

4: 91 percent / methanol / 5 h / Ambient temperature

5: 75 percent / H₂ / 5percent Pd/C / methanol / 2585.7 Torr

6: 144 mg / pyridine / dimethylformamide / 2 h / Ambient temperature

7: 58 percent / fuming nitric acid / 0.75 h / 0 °C

8: 87 percent / H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

9: pyridine / dimethylformamide / 0.5 h / Ambient temperature

10: 54 percent / conc. sulfuric acid / acetic acid / 4 h / 100 °C

With pyridine; sodium hydroxide; sulfuric acid; hydrogen; dihydrogen peroxide; nitric acid; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00047a017

Reference yield:

: 4655-68-9
2,5-Dimethoxy-1,4-benzoldicarbonitril

: 143430-53-9
2-(chloromethyl)-5,10-dimethoxy-3,7,8-trimethylpyrimido<4,5-g>quinazoline-4,9(3H,8H)-dione

Guidance literature:: Multi-step reaction with 11 steps

1: 71 percent / acetic anhydride, 90percent nitric acid / 0.25 h / Ambient temperature

2: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C

3: 73 percent / conc. sulfuric acid, aq. sodium nitrite / 70 °C

4: 75 percent / conc. sulfuric acid / Heating

5: 91 percent / methanol / 5 h / Ambient temperature

6: 75 percent / H₂ / 5percent Pd/C / methanol / 2585.7 Torr

7: 144 mg / pyridine / dimethylformamide / 2 h / Ambient temperature

8: 58 percent / fuming nitric acid / 0.75 h / 0 °C

9: 87 percent / H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

10: pyridine / dimethylformamide / 0.5 h / Ambient temperature

11: 54 percent / conc. sulfuric acid / acetic acid / 4 h / 100 °C

With pyridine; sodium hydroxide; sulfuric acid; hydrogen; dihydrogen peroxide; nitric acid; acetic anhydride; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00047a017