Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI)

Base Information

Chemical Name:Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI)
CAS No.:143430-48-2
Molecular Formula:C₁₂H₉ClN₄O₄
Molecular Weight:308.681
Hs Code.:
Mol file:143430-48-2.mol

Synonyms:Pyrimido[4,5-g]quinazoline-4,9-dione,2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI)

Suppliers and Price of Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI)

Chemical Property:

PSA：132.48000
LogP:1.44260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI)

There total 12 articles about Pyrimido[4,5-g]quinazoline-4,9-dione, 2-(chloromethyl)-1,6-dihydro-5,10-dihydroxy-7-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 143446-03-1
2-Bromomethyl-5,10-dihydroxy-7-methyl-3,8-dihydro-pyrimido[4,5-g]quinazoline-4,9-dione

: 143430-48-2
2-(chloromethyl)-5,10-dihydroxy-7-methylpyrimido<4,5-g>quinazoline-4,9(3H,8H)-dione

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; for 2.5h; Ambient temperature;
DOI:10.1021/jo00047a017

Reference yield:

: 5628-41-1
3,6-dicyano-1,4-dimethoxy-2-nitrobenzene

: 143430-48-2
2-(chloromethyl)-5,10-dihydroxy-7-methylpyrimido<4,5-g>quinazoline-4,9(3H,8H)-dione

Guidance literature:: Multi-step reaction with 11 steps

1: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C

2: 81 percent / H₂ / 5percent Pd on carbon / methanol / 3 h / 2585.7 Torr

3: 78 percent / acetic acid / 4.5 h / 40 °C

4: 78 percent / 10percent aq. sodium hydroxide / ethanol / 24 h / Heating

5: 69 percent / conc. sulfuric acid / 10 h / Heating

6: 76 percent / NO₂BF₄ / acetonitrile / 0.17 h / Ambient temperature

7: 92 percent / H₂ / 5percent Pd/C / methanol / 4 h / 2585.7 Torr

8: 80 percent / pyridine / benzene / 3.5 h / Ambient temperature

9: 62 percent / methanolic ammonia / sodium cyanide / 24 h / 80 °C

10: 62 percent / BBr₃ / benzene / 24 h / Heating

11: 91 percent / lithium chloride / dimethylformamide / 2.5 h / Ambient temperature

With pyridine; sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; ammonia; hydrogen; dihydrogen peroxide; boron tribromide; lithium chloride; sodium cyanide; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00047a017

Reference yield:

: 4655-68-9
2,5-Dimethoxy-1,4-benzoldicarbonitril

: 143430-48-2
2-(chloromethyl)-5,10-dihydroxy-7-methylpyrimido<4,5-g>quinazoline-4,9(3H,8H)-dione

Guidance literature:: Multi-step reaction with 12 steps

1: 71 percent / acetic anhydride, 90percent nitric acid / 0.25 h / Ambient temperature

2: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C

3: 81 percent / H₂ / 5percent Pd on carbon / methanol / 3 h / 2585.7 Torr

4: 78 percent / acetic acid / 4.5 h / 40 °C

5: 78 percent / 10percent aq. sodium hydroxide / ethanol / 24 h / Heating

6: 69 percent / conc. sulfuric acid / 10 h / Heating

7: 76 percent / NO₂BF₄ / acetonitrile / 0.17 h / Ambient temperature

8: 92 percent / H₂ / 5percent Pd/C / methanol / 4 h / 2585.7 Torr

9: 80 percent / pyridine / benzene / 3.5 h / Ambient temperature

10: 62 percent / methanolic ammonia / sodium cyanide / 24 h / 80 °C

11: 62 percent / BBr₃ / benzene / 24 h / Heating

12: 91 percent / lithium chloride / dimethylformamide / 2.5 h / Ambient temperature

With pyridine; sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; ammonia; hydrogen; dihydrogen peroxide; nitric acid; acetic anhydride; boron tribromide; lithium chloride; sodium cyanide; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00047a017