(S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Base Information

Chemical Name:(S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide
CAS No.:1353623-10-5
Molecular Formula:C₂₂H₂₇N₅O₃S
Molecular Weight:441.554
Hs Code.:

Synonyms:(S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Chemical Property of (S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Technology Process of (S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

There total 8 articles about (S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1353628-27-9
(S)-tert-butyl 2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate

: 162787-61-3
2-(methylsulfonamido)benzoic acid

: 1353623-10-5
(S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: (S)-tert-butyl 2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate; With hydrogenchloride; acetic acid; In water; for 2h;

2-(methylsulfonamido)benzoic acid; With pyridine; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; pH=8;

Reference yield: 20.0%

: (S)-5,6,7-trimethyl-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidine dihydrochloride

: 162787-61-3
2-(methylsulfonamido)benzoic acid

: 1353623-10-5
(S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: 2-(methylsulfonamido)benzoic acid; With pyridine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; pH=> 8;

(S)-5,6,7-trimethyl-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidine dihydrochloride; In N,N-dimethyl-formamide; for 6h;
DOI:10.1021/jm5017768

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1353623-10-5
(S)-N-(2-(2-(5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran; hexanes / -78 - -40 °C

2.2: -78 - -40 °C

2.3: -78 - 20 °C

3.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

4.1: acetic acid / 0.5 h / 90 °C

5.1: hydrogenchloride; acetic acid / water / 2 h

5.2: 20 °C / pH 8

With hydrogenchloride; sodium bis(trimethylsilyl)amide; hydrazinium monoacetate; caesium carbonate; acetic acid; In tetrahydrofuran; hexanes; ethanol; water; N,N-dimethyl-formamide;